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<p>이러한 대체 세포내이입 경로를 활용함으로써, CIE 기반 LYTAC은 향상된 표적 선택성, 세포 흡수율 증가, 그리고 더 넓은 조직 접근성을 제공할 수 있습니다. 조직인자(TF)는 짧은 세포내 C-말단 꼬리와 막관통 도메인을 통해 세포막에 고정된 막관통 당단백질입니다. 147 TF 의 세포외 영역은 응고인자 VII(FVII) 및 활성화형인 FVIIa에 높은 친화도로 결합합니다. TF는 콜레스테롤이 풍부한 지질 래프트에 풍부하게 존재하며, 카베올린-1과 상당한 공동 위치를 나타냅니다. 특히, FVIIa-TF 복합체는 클라트린 비의존적 경로를 통해 세포 내로 유입되는데, 이는 TF가 표적 단백질 분해에 활용될 수 있는 잠재적인 CIE 가능 LTR임을 시사합니다. 또 다른 대표적인 CIE 메커니즘은 LDL 수용체의 유도성 분해인자(IDOL)에 의해 조절됩니다. 148 IDOL은 저밀도 지질단백질 수용체(LDLR)의 세포질 꼬리 부분의 유비퀴틴화를 촉진하여 클라트린이나 카베올라와는 독립적으로 분해되도록 표지합니다. 유비퀴틴화된 LDLR은 수송에 필요한 엔도솜 분류 복합체(ESCRT) 기계에 의해 인식되어 다소포체(MVB)로 이동하고, 최종적으로 리소좀 분해를 겪습니다. <a class="seoquake-nofollow" href="https://zzgtv.com" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">짱구스포츠</span></a> <a class="seoquake-nofollow" href="https://totogal.net/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">토토갤</span></a> <a 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