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<p>그림 3 그림 3. 시간영양학: 식사 시간이 소화기관 질환에 미치는 영향. 전체 캡션 표시 그림 뷰어 간에서, 활동적인 단계에서 칼로리 섭취를 줄이지 않고 TRF를 시행하면 식이 유도 비만 마우스에서 지방간이 개선되고 담즙산 생성이 증가합니다[ 69 ]. 비만 및 지방간 예방에 대한 TRF의 유익한 효과는 Cry1/2 이중 녹아웃, 간 특이적 Bmal1 및 Rev-erbα/β 녹아웃 마우스를 포함하여 핵심 시계 구성 요소가 결핍된 여러 마우스 모델에서도 유지됩니다[ 72 ]. 이러한 결과는 리듬 생리를 매개하는 데 있어 비정형 시계 조절자의 역할을 더욱 시사합니다. 인간의 경우, 12주 동안 10시간의 TRE 창을 적용했을 때 간 트랜스아미나제[알라닌 아미노트랜스퍼라제(ALT) 및 아스파르트산 아미노트랜스퍼라제(AST)]의 혈장 수치가 감소하는 경향을 보였습니다[ 73 ]. TRF를 적용한 간의 전사체 분석 결과, 염증 신호 전달 및 당지질 대사에 관여하는 유전자의 발현이 감소한 것으로 나타났습니다[ 74 ]. MASLD 외에도 TRF는 간세포 특이적 세린 및 아르기닌 풍부 스플라이싱 인자 3(SRSF3-HKO [ 75 ]) 삭제를 통한 자발적 종양 발생 마우스 모델과 노화된 수컷 마우스에서도 간세포암 발생률을 감소시켰습니다 [ 76 ]. 또한, 활동기 동안 8시간 동안 음식 섭취를 허용하고 저항 운동 훈련(TRF + RT)을 3주 동안 병행한 TRF는 간의 호흡 교환율, 에너지 소비량 및 미토콘드리아 호흡을 개선했습니다. 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