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<p>14 , 15 , 16 JYP0322의 구조적 최적화는 ROS1 결합 힌지 상호작용을 유지하면서 TRKA 회피를 향상시켜 중추신경계 부작용을 줄이고 신경학적 이상반응 발생률을 낮추어 전반적으로 안전성 프로파일을 개선합니다. 14 , 15 , 16 JYP0322는 ROS1 양성 비소 세포폐암(NSCLC) 환자 에서 탁월한 효능을 입증했습니다 . 티로신 키나제 억제제(TKI) 치료 경험이 없는 환자에서 객관적 반응률(ORR)은 95.7%였습니다. 이는 다른 ROS1-TKI의 보고된 ORR과 유사한 수준입니다. 예를 들어, 레포트렉티닙(TRIDENT-1에서 79%), 14 엔트렉티닙(ALKA-372-001/STARTRK-1/2 통합에서 68%), 13 , 23 우네크리티닙(1/2상 임상시험에서 80.2%), 24 탈레트렉티닙(TRUST-I/II에서 88.8%) 15 의 ORR은 모두 68%~88.8% 범위였습니다. JYP0322는 이전에 ROS1 TKI 치료에 실패한 환자에서도 약물 내성을 극복하는 강력한 능력을 보여주었으며, 본 임상시험에서 TKI 사전 치료 환자에서의 ORR은 52.6%로 매우 우수했습니다. <a class="seoquake-nofollow" href="https://mukssa-news.com/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">먹튀검증</span></a> <a class="seoquake-nofollow" href="https://xn--910br1nf9g2g92y.com/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">토토솔루션</span></a> <a class="seoquake-nofollow" href="https://xn--910br1nf9g2g92y.com/%EC%B9%B4%EC%A7%80%EB%85%B8%EC%86%94%EB%A3%A8%EC%85%98/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span 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